An ionic forcefield for nanoparticles

first_img Nanoparticles shine with customizable color “The great thing about ionic liquids is that every small change you make to their chemistry results in a big change in their properties,” said Christine Hamadani, a former graduate student at SEAS and first author of the paper. “By changing one carbon bond, you can change whether or not it attracts or repels proteins.”Hamadani is currently a graduate student at Tanner’s lab at the University of Mississippi.The researchers coated their nanoparticles with the ionic liquid choline hexenoate, which has an aversion to serum proteins. Once in the body, these ionic-liquid coated nanoparticles appeared to spontaneously attach to the surface of red-blood cells and circulate until they reached the dense capillary system of the lungs, where the particles sheared off into the lung tissue.“This hitchhiking phenomenon was a really unexpected discovery,” said Mitragotri. “Previous methods of hitchhiking required special treatment for the nanoparticles to attach to red blood cells and even then, they only stayed at a target location for about six hours. Here, we showed 50 percent of the injected dose still in the lungs after 24 hours.”The research team still needs to understand the exact mechanism that explains why these particles travel so well to lung tissue, but the research demonstrates just how precise the system can be.“This is such a modular technology,” said Tanner, who plans to continue the research in her lab at University of Mississippi. “Any nanoparticle with a surface change can be coated with ionic liquids and there are millions of ionic liquids that can be tuned to have different properties. You could tune the nanoparticle and the liquid to target specific locations in the body.”“We as a field need as many tools as we can to fight the immune system and get drugs where they need to go,” said Mitragotri. “Ionic liquids are the latest tool on that front.”The research was co-authored by Morgan J. Goetz. Related Tracking nanoparticles Samir Mitragotri harnesses blood cells to help nanoparticles cross biological barriers Findings could help in developing treatment for pulmonary disease Hitchhiking his way to better drug delivery Display screens, security tags may benefit from control and color creation Nanoparticles are promising drug delivery tools, offering the ability to administer drugs directly to a specific part of the body and avoid the awful side effects so often seen with chemotherapeutics.But there’s a problem. Nanoparticles struggle to get past the immune system’s first line of defense: proteins in the blood serum that tag potential invaders. Because of this, only about 1 percent of nanoparticles reach their intended target.“No one escapes the wrath of the serum proteins,” said Eden Tanner, a former postdoctoral fellow in bioengineering at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS).Now, Tanner and a team of researchers led by Samir Mitragotri, the Hiller Professor of Bioengineering and Hansjorg Wyss Professor of Biologically Inspired Engineering at SEAS, have developed an ionic forcefield that prevents proteins from binding to and tagging nanoparticles.In mouse experiments, nanoparticles coated with the ionic liquid survived significantly longer in the body than uncoated particles and, surprisingly, 50 percent of the nanoparticles made it to the lungs. It’s the first time that ionic liquids have been used to protect nanoparticles in the blood stream.“The fact that this coating allows the nanoparticles to slip past serum proteins and hitch a ride on red blood cells is really quite amazing because once you are able to fight the immune system effectively, lots of opportunities open up,” said Mitragotri, who is also a core faculty member of Harvard’s Wyss Institute for Biologically Inspired Engineering.The research is published in Science Advances.,Ionic liquids, essentially liquid salts, are highly tunable materials that can hold a charge.“We knew that serum proteins clear out nanoparticles in the bloodstream by attaching to the surface of the particle and we knew that certain ionic liquids can either stabilize or destabilize proteins,” said Tanner, who is now an assistant professor of chemistry and biochemistry at the University of Mississippi. “The question was, could we leverage the properties of ionic liquids to allow nanoparticles to slip past proteins unseen.”last_img read more

For the first time, a Native American may oversee U.S. policies on tribal nations

first_imgIf she wins Senate approval, Democratic Rep. Deb Haaland of New Mexico will become the first Native American Cabinet secretary. But perhaps more importantly, as secretary of the Interior, the enrolled member of the Pueblo of Laguna would also become the first Native person to oversee federal policies involving the 574 federally recognized tribal nations as well as the national parks and public lands. For many, her selection brings history full circle.After learning of her nomination, Haaland, a 35th-generation New Mexican who in 2018 became one of the first two Native American women elected to Congress, tweeted, “A voice like mine has never been a Cabinet secretary or at the head of the Department of Interior.” The Gazette asked some members of the community for their thoughts on the historic nomination.,Victor A. Lopez-Carmen, M.D. ’23Enrolled member of the Crow Creek Sioux TribeStudent at Harvard Medical SchoolBefore Medical School, I got to clerk for the Natural Resources Committee in the U.S. House of Representatives, a committee Rep. Haaland is the vice-chair of. Working with her and her staff on committee hearings and legislation, especially those concerning missing and murdered Indigenous women, was an experience I will always be grateful for. This is because Congresswoman Haaland exemplifies the powerhouse nature of Native American women. The extent to which Native American women lead, guide, and build our communities, as they have done for millennia, has too often gone unrecognized.Many of America’s most dignified and noble leaders have always been, and always will be, Indigenous women. Now soon-to-be Secretary Haaland — a confident, contemporary political leader — shows young Indigenous girls and girls of color how high they can go, which will positively impact this country for generations to come.,Heidi Brandow, M.Des. ’21Diné/Kanaka MāoliStudent at Harvard Graduate School of DesignIt’s a historic first for Native people. Frankly, it’s a move in the right direction, especially given the fact that the nominee is a female Native leader. Native representation at the Department of Interior is long overdue. It’s an exciting silver lining, given the challenging events over the past year.Rep. Haaland has a thorough understanding of the needs of Native people and communities. As a member of the Laguna Pueblo tribe and a longtime community organizer, she is familiar with issues affecting Native Americans and is committed to fighting for Indigenous communities.Under Trump, the Department of Interior sold and leased formerly protected lands at record numbers, thereby deteriorating environmental protections and often thrusting sacred landmarks and national monuments into the hands of developers. Often, lopsided land sales and leases of formerly protected lands were near or within tribal boundaries. Haaland’s nomination and her presence at the helm of the Department of Interior will help re-establish trust and a continued commitment among respective Native nations working with the department.,Eric Henson, M.P.P. ’98Citizen of the Chickasaw NationAdjunct Lecturer in Public Policy, Harvard Kennedy School of GovernmentRep. Deb Haaland’s likely ascension to the position of secretary of the Interior is welcome news throughout Indian Country. Her nomination sends a strong message that the incoming administration believes Native people deserve a seat at the table when many of the most important discussions take place at the highest levels of the U.S. government.Seeing a proud, strong Native woman in such a senior position will brighten my day every day, and I expect her tenure as secretary to be far more than merely symbolic to those of us who care about Native inclusion at the top of the federal government. Since her election to Congress, Rep. Haaland has been very active, lending her name to more than 50 draft bills. This potential legislation showcases some of the areas in which she is likely to remain a force for tribal people and issues that Native America cares about. This is not nearly an exhaustive list, but so far, she has used her drafting pen to work toward greater wilderness preservation, and she is a strong advocate for expanded broadband access on tribal lands, which is a longstanding problem that has become even more crucial as we continue to battle the coronavirus pandemic while simultaneously attempting to educate thousands of Native children via distance learning, often in remote rural settings. Furthermore, Rep. Haaland has consistently spoken out about the need to address the lingering harms of the Indian boarding school era, and she intends to implement an aggressive policy to overturn many of the offensive place names that still exist throughout the U.S.; place names that by their very nature insult tribal people on an ongoing basis.,Megan HillCitizen of the Oneida Nation of WisconsinProgram Director, Harvard Project on American Indian Economic DevelopmentI heard a collective cheer across Indian Country when Rep. Deb Haaland was tapped to lead the U.S. Department of Interior by then-President-elect Biden. Facebook, Twitter, and Instagram were alive with posts celebrating the announcement, highlighting her groundbreaking career of service and leadership, filled with “firsts.” But, mostly, the cheers were of collective honor: She is one of our own. As a citizen of Laguna Pueblo, her success shines light on and gives voice to Natives across the country.Once confirmed, she will step into a department with a legacy of anti-Indian policies engineered to dispossess Indigenous peoples of land and resources. While she will have Cabinet-level decision-making power, she will face competing interests from protecting the environment and elevating Indigenous priorities to managing demands from big oil and climate change deniers. Indian Country may need to adjust expectations, and she will need our continued support. I am reassured, though, that for the first time in history, the Department will be led with Indigenous values and integrity. In a statement she said, “I will be fierce for all of us, for our planet, and for all of our protected land”… And I believe she will.,Amy Besaw Medford, Ed.M. ’02Enrolled member of the Brothertown Indian Nation and of Menominee descentResearcher at the Harvard Project on American Indian Economic DevelopmentWhen I was a young girl, it was hard to see female leadership outside my tribe as I was raised on military bases. But I saw the important role that women played within my tribe and within my family. The older I got, the more I saw the generation above me filling in leadership roles, whether it was tribal leaders on a regional or national scale. But it was usually in the tribal context: Indians supporting Indians.When I entered the Ed School’s master’s program, there was just one senator who was Native: Ben Nighthorse Campbell [senator from Colorado from 1993 to 2005]. Now, there is not just one Native woman in Congress, there are three! And they can support each other and be part of that great alliance of women of color and their allies. As a mother, it gives me hope for my daughter and my son, who can see what is a clear recognition of the roles that women can play on a national scale.As secretary of Interior, Haaland will be the first Native woman who will be responsible for policies that will affect Native American communities. That’s very powerful. She’s better able to represent the interests of Indigenous communities. As a Native person, Haaland doesn’t have to be given an Indian 101 course, or be taught about tribal sovereignty. She doesn’t have to be given the history of treaties between the U.S. government and the Native nations, and how the government failed its responsibilities. Haaland also knows from direct experience how Native nations govern themselves. She was a tribal administrator: She gets the nuances that exist in Indian country. As the first people of this land, I love that we have her protecting our land. For Native people, it’s inspiring, prideful, and empowering to see Haaland, a strong woman fighting for our rights and for the protection of our land. It is going to be a tough job; she won’t be able to please everyone. But I have faith in her leadership and I think she will serve our nation well.,Meredith VastaMember of the Turtle Mountain Band of Chippewa IndiansCollections Steward at Peabody Museum of Archaeology and Ethnology at Harvard UniversityAs a Turtle Mountain Chippewa woman and museum professional, the appointment of Haaland is significant for several reasons. First, it is long overdue that the Indigenous communities most directly impacted by the success or failure of the Department of the Interior has someone with both lived experience of these impacts, as a citizen of the Laguna Pueblo, and policy experience as a Western legislator. This division is responsible for meeting the trust obligations of the federal government with hundreds of Native Nations, like my own, with whom they have entered into solemn political agreements, or treaties.As a museum professional, this division also funds the repatriation efforts of tribes through the Tribal Historic Preservation program, a critically important obligation tribes have to bring their relatives home. This division is woefully underfunded, making it hard for tribes to fully research and return their ancestors to their homelands or engage in necessary consultation with the museums that may hold them.As a Native woman, soon-to-be Secretary Haaland’s advocacy for missing and murdered Indigenous women underscores for me her connection to issues directly affecting Native communities, and I am certain that advocacy will continue in her new role.Interviews were edited for length and clarity “A Conversation with Congresswoman Deb Haaland,” moderated by Linda Bilmes, Daniel Patrick Moynihan Lecturer of Public Policy at the Harvard Kennedy School, is available for viewing on the Institute of Politics website.last_img read more

Olympics: Mexicans to watch in London

first_img MEXICO CITY – Keep an eye on these Mexican athletes at the London Games: Paola Espinosa, Mexico City, diving: The three-time Olympian won bronze in 2008 in Beijing in the 10-meter synchronized platform with partner Tatiana Ortiz. Espinosa, who carried the flag for the Mexican delegation in 2008, took bronze in the 10-meter platform at the World Championships in 2011 and gold in the 10-meter platform, synchronized platform and synchronized springboard at last year’s Pan American Games. Fernanda González, Mexico City, swimming: She holds the country’s record in the long-course 50-, 100-and 200-meter backstrokes and short-course 50-, 100-and 200-meter backstrokes. She competed in the Beijing Games but didn’t medal. Victoria Montero, Toluca, badminton: She enters London as Mexico’s lone representative in sport after winning bronze at last year’s Pan American Games. She won gold in the singles and doubles competition at the Central American and Caribbean Games in 2010. Horacio Nava, Chihuahua, race walking: He’s improved greatly since placing sixth in Beijing in 2008, as he won the 50-kilometer (31-mile) race at the Central American and Caribbean Games (3:56.46) and Pan American Games (3:48.58) in 2010 and 2011, respectively. Éder Sánchez, Tlalnepantla de Baz, race walking: He’s coming off a first-place finish at the Central American and Caribbean Games in Puerto Rico, when he won the 20-kilometer race (12.4 miles) in 1:22:32 in 2010. A year later, he placed 15th in the event at the most recent World Championships and sixth at the Pan American Games. Óscar Soto, Mexico City, modern pentathlon: The gold medalist at the Pan American Games in 2011 is a strong favorite to occupy a spot on the pedestal in London. He finished eighth in Beijing 2008, second at the World Cup 2009 in Mexico City, first at the Central American and Caribbean Games 2010 in Guatemala and second at the Open Senior Hungarian Championship, held in June in Budapest. Óscar Valdez, Nogales, boxing: After losing his first bout at the Olympics in 2008, Valdez is in position to contend for a medal in London, as he’s coming off a silver medal-winning performance in the bantamweight division at the Pan American games in 2011. In 2008, at the age of 17, he became the first Mexican to win the youth World Amateur Boxing Championships when he took gold in the featherweight division. By Dialogo July 17, 2012last_img read more

The town of Kutina has sold a resort on Mali Lošinj

first_imgPursuant to the decision of the 13th session of the City Council of the City of Kutina, a decision was made to sell the real estate, ie the Čikat rest area in Zlatna uvala on Mali Lošinj, which has so far been majority owned by the City of Kutina.After the decision on the sale of the resort was made at the 9th session of the City Council, which was made by the City of Kutina and other co-owners, namely the City of Popovača and the Municipality of Velika Ludina, this process continues. The resort, which was first estimated at HRK 7,8 million, reached HRK 14.120.000 with a new estimate, and will be bought by the Zagreb company FIL-ADRIA TURIST dooTheir offer was approximately HRK 2 million higher than the offer of the company JADRANKA HOTELI from Mali Lošinj. The funds that the city of Kutina will earn in this sale are around HRK 7 million, while it is planned to invest from the obtained funds in one of the capital projects in the city of Kutina.Photo: Kutina.inThe mayor of Kutina, Zlatko Babić, pointed out in the discussion that the times when Petrokemija managed Lošinj and invested large funds there have passed. ” That is no more, ownership relations must be established, there are several lawsuits that have no end in sight, and we can never be owners there. We cannot promise anyone that this can be arranged and that we can spend our summers there as before, because we will never be in that position again.”Babic pointed out.The subject of the new debate that will follow when the funds are raised will be in which capital project the money will be invested. Whether it will be an indoor pool, whether it will be a Home for the elderly and infirm, or something third will be seen, but the sale of this valuable property, as has been said many times, should not be spent on patching budgets or some small works, they point out. from the town of Kutina.last_img read more

Short and effective – Bahamas with Love

first_imgWe will follow how the whole campaign will develop further, because with the publication of one video, we certainly cannot talk about a complete campaign. But now, at a time of crisis caused by the coronavirus, they have used (recycled) the same content, but added a narrative according to the current situation. In an attempt to attract foreign tourists and present the Bahamas as an attractive tourist destination, the Bahamas hired popular musician Lenny Kravitz for their campaign. So last year a new, multi-channel creative campaign was launched with Bahamian-American rock legend Lenny Kravitz and the lyrics of his hit song Fly Away. “What matters the most is that we come together as one. You were there for us and when the storm passes we’ll be here for you. “center_img “From The Bahamas with Love” is the name of a new campaign that was announced through a short and effective video, with an even better narrative. The campaign is, of course, thematically related to the current crisis situation caused by the coronavirus. PS We are also waiting for the CNTB’s move to address a video or similar campaign, as well as other national tourist boards, in accordance with the time of the coronavirus. Short and effective.last_img read more

Alleged fraud on three Italian pension funds results in seven arrests

first_imgNone of them is currently or has been an employee of any of the three funds.The alleged crimes are thought to have netted the suspects almost €80m, with €50m taken from the Cassa dei Ragionieri, €7m from INPGI and €20m from Enpam.The nature of the alleged crimes, which date back to 2009, is yet to be fully clarified.It is alleged, however, that Cassa dei Ragionieri was subtracted the sum through asset manager Adenium, with the funds being shifted from another company – HPS, owned by Gianluca Selvi – to tax havens and then back to the suspects’ account.Regarding INPGI and Enpam, Milan prosecutor Gaetano Ruta justified the arrests with the allegation that Sopaf, which was managing part of the pension funds’ assets, sold the two schemes stakes in Fondo Immobili Pubblici (FIP), a state-run real estate fund, at unjustifiably high prices, making an illicit profit.An Enpam spokesperson specified that the returns form the stakes in FIP owned by Enpam have been positive, with no loss made on that investment.Between 2011 and 2012, Enpam was involved in a scandal that saw former chairman Eolo Parodi, other former employees and advisers being arrested under the suspicion of wrongdoing.They are soon to be tried for charges relating to ‘toxic’ investment in CDOs that had put a sizeable part of Enpam’s finances at risk.Enpam’s, which currently has €15bn in assets, recently turned around its investment policy, scaling back on riskier assets Seven people have been arrested on suspicion of various crimes including conspiracy to commit fraud, bankruptcy, embezzlement and tax evasion at the expense of three major Italian pension funds – the accountants’ pension scheme Cassa di Previdenza dei Ragionieri, the journalists’ scheme INPGI and the doctors’ scheme Enpam.The suspects are well-known personalities in the Italian finance sector revolving around Italian investment company Sopaf.They have been named by Italian media as Ruggero Magnoni, former European vice-president of Lehman Brothers and chairman of the Italian arm of Nomura; his brothers Aldo Magnoni, founder of Oak Fund, and Giorgio Magnoni, chief executive at Sopaf; and the former’s son Luca Magnoni, a board member at Sopaf.The Guardia di Finanza (Italian financial crime police) has also arrested Andrea Toschi, former chairman of Arner Bank and chief executive at Sopaf-owned asset manager Adenium, Alberto Ciaperoni of Sopaf and accountant Gianluca Selvi.last_img read more

Fiduciary management fees of little concern to pension funds – survey

first_imgFees are one of the least important considerations to those using fiduciary management solutions in the UK, despite a perceived lack of transparency on costs, according to Aon Hewitt.The consultancy’s 2016 Fiduciary Management Survey found that the cost of fiduciary management was only the seventh most important quality indicator to UK funds, behind concerns such as a provider’s track record or ability to explain its investment process.The survey of more than 370 pension funds, however, found a noticeable split in attitude between those already employing fiduciary management – where only 13% cited fees as an important indicator of quality – and those only considering outsourcing, at which point the number of schemes concerned rose to 34%.Sion Cole, head of European distribution at the consultancy, told IPE Aon Hewitt was pushing for greater clarity on fees and complete separation of any costs incurred while employing fiduciary managers. He said it was important trustees understood “all of the fees they incur” and that pension funds were able to ascertain “who gets paid and what they get paid to do”.To this end, the consultancy is in favour of unbundling any fees levied as a result of fiduciary management agreements.“What we are looking for,” Cole said, “is total expense ratios, but not just the total-expense-ratio headline number.“[We are also looking for] the total expense ratio broken down into the individual areas so trustees can make sure they understand that’s the total fee they are incurring, and that this is who is making money from this transaction.”He did not back the idea of a standardised approach to charging for asset management services, however, noting the flexibility currently allowed providers to vary their approach.“Clarity,” he said, “is the number one area we are trying to promote.”The findings come as the UK debates how to improve fee transparency, following a widely criticised report by the Investment Association on the retail investment sector likening hidden fees to the Loch Ness monster. The report was dismissed by Mark Fawcett, CIO at the National Employment Savings Trust and chair of the IA’s independent advisory board on costs, who said the board felt there was “scope for improvement” about how fees were disclosed. Cole also rejected the notion of developing a standardised way of measuring the industry’s performance, with the consultancy’s survey finding that 87% of pension funds preferred to have relative-performance measurement taking into consideration each fund’s goals.“No two pension schemes are the same,” he said. “We therefore believe it is important, when implementing a fiduciary solution, that trustees make sure their provider creates a bespoke benchmark that accurately reflects their precise objectives and their unique liability profile.”Cole also noted, across Aon Hewitt’s sample of UK funds, a growing interest in fiduciary management from schemes with more than £100m in assets.The survey also found that, compared with 2014 – when 22% of larger schemes surveyed had availed themselves of fiduciary management – the percentage had now increased to 40%, bringing it close to the survey’s average of 45% across all UK funds surveyed.last_img read more

Swire Seabed Confirms Siem Stingray Charter

first_imgSwire Seabed said it has signed a bareboat charter with Siem Offshore for up to three years bareboat of Siem’s LCV, Siem Stingray.The contract was announced by Siem Offshore on Oslo Stock Exchange earlier on Monday, without disclosing the other charter party.Siem Stingray, which will be re-named Seabed Stingray, is an IMR, construction and survey vessel of the VARD design.The vessel has a deck space of 1350 m² and is equipped with a 250 tonne offshore crane ans will also have two heavy duty work class ROVs.The contract will see Swire Seabed operate the vessel in the IMR, construction support and renewable sectors, with a particular focus on North European and West African markets.“While the market environment remains challenging, Swire Seabed continues to invest in new technology, assets, and is increasing capacity in engineering, survey and project execution. This bareboat charter increases the scale and flexibility of Swire Seabed’s fleet, and expresses our confidence in the quality of our service portfolio and the resilience of our clients in the subsea industry,” says CEO, Swire Seabed, Arvid Pettersen.last_img read more

Chad Astaphan releases debut music video

first_imgEntertainmentLocalNews Chad Astaphan releases debut music video by: – June 7, 2012 Share Sharing is caring! Tweet Sharecenter_img Share 52 Views   4 comments One of Dominica’s newest rising stars, Chad Astaphan, has released his debut music video for his hit summer single “Breath Away”.Since copping the 1st runner up position in the Q Talent Search Competition, Astaphan has been working on his solo career.He has signed unto Fully Grown Entertainment/Record and has also formed his own entertainment company; C.A Entertainment.The single which is the first on his summer album “Playback” is set to be released in July of this year.According to Astaphan, “Breath Away” has been very popular in Dominica and internationally but the video has just boosted its life.He explains that the concept for the video was to be like a dream or daydream in the middle of a dessert looking for someone that he seems to see but can’t touch.“Breath Away is a feel good dancy song with a catchy hook. I wanted a video that was not typical and normal, I wanted something different and interesting and the video speaks for itself!”The song can be purchased on iTunes: music video was produced, shot, directed and edited by 365 MMP.[youtube][/youtube]Dominica Vibes Newslast_img read more

SportMod Challenge winner earns $2,000 at Davenport

first_imgDAVENPORT, Iowa – Karl Chevrolet Northern SportMods take over the spotlight in a $2,000 to win main event on Friday, June 12 at Davenport Speedway.The IMCA SportMod Challenge will use a draw/redraw format and all racing will be on the quarter-mile oval.Pit gates open at 4:30 p.m. and the grandstand opens at 5 p.m., with racing at 6:45 p.m.Spectator admission is $15 for adults, $14 for seniors and free for kids 12 and under when accompanying a paid adult. Pit passes are $30.Also racing that evening will be Xtreme Motor Sports IMCA Modifieds and IMCA Late Models.For additional information, call 563 652-5302 or 563 326-5338 on race day. The track website is read more